Cold Spring Harbor Laboratory  
Contact Us | Faculty & Staff Directory

Harbor Transcript

 

Contact Public Affairs

We want to hear from you.
Contact Us

Follow us on

  facebook-icon twitter-icon instagram-icon3 youtube-icon wordpress-icon2
  rss-icon email-icon linkedin-icon flipboard icon

pancreatic organoids
To trace the cause of metastasis in pancreatic cancer, the CSHL team used cells sampled from 6 mice to grow paired sets of pancreatic organoids — balls of cells that develop in 3-D culture. The mice had gene mutations that induced pancreatic ductal cancer. In each of the mice, normal pancreatic ductal cells were compared with cells from the same animals in three distinct stages: pre-malignant, malignant, and metastatic. In this way, the team was certain to be comparing "apples to apples." Experiments revealed that cancer cells became capable of metastasis via an epigenetic reprogramming of gene enhancers, reverting them to an earlier developmental state characterized by proliferation and increased mobility. Read more
 
CSHL in the News

Quanta Magazine
Beating the odds for lucky mutations
August 16, 2017

Nature
China launches brain-imaging factory
August 15, 2017

Southeast Produce Weekly
Doubling down on tomatoes: Research breakthrough could double yields for tomatoes and other crops
August 11, 2017

The Scholarly Kitchen
Beyond labels - Does the type of business matter?
August 8, 2017

PLOS Neuroscience Community...


Read more...

  Latest News